反应详情

A mixture of 62.7 (0.23 mmol), 7.5 (76 mg, 0.19 mmol), and Cs2CO3 (226 mg, 0.69 mmol) in DMF (2.3 mL) was stirred overnight at room temperature. The mixture was diluted with EtOAc, washed with water and brine, dried (Na2SO4), and concentrated. The crude product was chromatographed on silica gel (15-45% EtOAc/hexane) to afford 62.8 (94 mg, 75%) as a white solid.

1. washwashed with water and brine
2. dry with materialdried (Na2SO4)
3. concentrationconcentrated
4. customThe crude product was chromatographed on silica gel (15-45% EtOAc/hexane)