Methyl iodide → 3-Chloro-4-fluorophenyl methyl sulfide

HRID 1675605Notes

Reaction equation

HRID 1675605 reaction equation
IC.[Cl:3][C:4]1[CH:5]=[C:6]([SH:11])[CH:7]=[CH:8][C:9]=1[F:10].[C:12](=O)([O-])[O-].[K+].[K+]>CN(C=O)C.O>[CH3:12][S:11][C:6]1[CH:7]=[CH:8][C:9]([F:10])=[C:4]([Cl:3])[CH:5]=1

Participants

6

Reactant 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 27341973-Chloro-4-fluorobenzene-1-thiol

Product 1

HCID 552207093-Chloro-4-fluorophenyl methyl sulfide

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6228DimethylformamideSolvent

Procedure

Iodomethane (1.15 ml) was added to a stirred mixture of 3-chloro-4-fluoro-benzenethiol (3.0 g), potassium carbonate (2.48 g) in DMF (20 ml) and left overnight. The reaction was diluted with water and extracted with diethylether, the organics were dried and evaporated under reduced pressure, yield 4.3 g.

Workup

  1. extractionextracted with diethylether
  2. customthe organics were dried
  3. customevaporated under reduced pressure, yield 4.3 g

Sources & evidence

ORD record
ord-551a4db276af4c1bb7eb2171335381ab
Source dataset
uspto-grants-2011_08
Patent number
US08003703B2

Reaction notes

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