反应详情

温度

40 °C

Sodium hydride (60% disp. oil, 0.24 g) was added to a solution of (2-hydroxyphenoxy) acetic acid (0.5 g) in DMF (20 ml) and stirred at 40° C. for 30 min. The product from example 7 step (ii) (0.62 g) was added, then the mixture heated at 75° C. for 30 h. 2M Sodium hydroxide solution was added and extracted with ethylacetate. The aqueous layer was acidified with 2M hydrochloric acid and extracted with ethyl acetate. The organics were dried, evaporated under reduced pressure and the residue purified by RPHPLC, yield 0.21 g.

1. temperaturethe mixture heated at 75° C. for 30 h
2. extractionextracted with ethylacetate
3. extractionextracted with ethyl acetate
4. customThe organics were dried
5. customevaporated under reduced pressure
6. customthe residue purified by RPHPLC, yield 0.21 g