Dichloromethane → HCID 18449380, compound

HRID 1675768Notes

Reaction equation

HRID 1675768 reaction equation
C([CH:5]([N:9]1[C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=2[N:11]([C:18]2[S:19][CH:20]=[C:21]([S:23]([CH3:25])=[O:24])[N:22]=2)[C:10]1=[O:26])[C:6]([O-:8])=[O:7])(C)(C)C.C(Cl)Cl>C(C(O)=O)(F)(F)F>[CH3:25][S:23]([C:21]1[N:22]=[C:18]([N:11]2[C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=3[N:9]([CH2:5][C:6]([OH:8])=[O:7])[C:10]2=[O:26])[S:19][CH:20]=1)=[O:24]

Participants

4

Reactant 2

HCID 6344DichloromethaneHCID 86619735HCID 86619735, compound

Product 1

HCID 18449380HCID 18449380, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

(±)-tert-Butyl {3-[4-(methylsulfinyl)-1,3-thiazol-2-yl]-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl}acetate from Step D (100 mg, 0.254 mmol) was dissolved in CF3CO2H (3 mL) and CH2Cl2 (3 mL) and the mixture was stirred at ambient temperature for 3 h, then concentrated in vacuo to give the title compound. MS: m/z=338 (M+1).

Workup

  1. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-1f5810060d984d66af8f7d995a8fb42c
Source dataset
uspto-grants-2011_08
Patent number
US08003792B2

Reaction notes

Loading…