Trifluoroacetic acid → HCID 67337580, compound

HRID 1675784Notes

Reaction equation

HRID 1675784 reaction equation
C(C(O)=O)(F)(F)F.[O:8]=[C:9]1[C:17]2([CH2:22][CH2:21][O:20][CH2:19][CH2:18]2)[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[N:10]1[CH2:23][C:24]([O:26]C(C)(C)C)=[O:25]>C(Cl)Cl>[O:8]=[C:9]1[C:17]2([CH2:22][CH2:21][O:20][CH2:19][CH2:18]2)[C:16]2[C:11](=[CH:12][CH2:13][CH2:14][CH:15]=2)[N:10]1[CH2:23][C:24]([OH:26])=[O:25]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86619737HCID 86619737, compound

Product 1

HCID 67337580HCID 67337580, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

CF3CO2H (1 mL) was added to a solution of tert-butyl (2-oxo-2′,3′,5′,6′-tetrahydrospiro[indole-3,4′-pyran]-1(2H)-yl)acetate from Step B (55.0 mg, 0.173 mmol) in CH2Cl2 (3 mL). After 3 h, the mixture was concentrated in vacuo to give the title compound. MS: m/z=262 (M+1).

Workup

  1. concentrationthe mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-b40aa94eeaf44a99a8310ec6e28878c4
Source dataset
uspto-grants-2011_08
Patent number
US08003792B2

Reaction notes

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