HCID 67351938, compound → HCID 58653690, compound

HRID 1676023Notes

Reaction equation

HRID 1676023 reaction equation
[N:1]1(/[C:10](/[C:17]2[CH:22]=[CH:21][C:20]([CH2:23][CH3:24])=[CH:19][CH:18]=2)=[CH:11]\[C:12]([O:14]CC)=[O:13])[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[CH:2]1>Cl>[N:1]1(/[C:10](/[C:17]2[CH:22]=[CH:21][C:20]([CH2:23][CH3:24])=[CH:19][CH:18]=2)=[CH:11]\[C:12]([OH:14])=[O:13])[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[CH:2]1

Participants

3

Reactant 1

HCID 67351938HCID 67351938, compound

Product 1

HCID 58653690HCID 58653690, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A solution of ethyl (2Z)-3-(1H-benzimidazol-1-yl)-3-(4-ethylphenyl)-2-propenoate (60 mg, 187 μmol) in hydrochloric acid (10 mL of a 5N solution) was stirred at room temperature for 72 hours, and then heated at reflux for 6 hours. The solution was cooled to room temperature, and evaporated in vacuo to afford the title compound, [LCMS (Method A, Mobile Phase I) RT=6.63 min, MH+ 294].

Workup

  1. temperatureheated
  2. temperatureat reflux for 6 hours
  3. customevaporated in vacuo

Sources & evidence

ORD record
ord-e942d07abbd844eeac4752b0777948fb
Source dataset
uspto-grants-2011_08
Patent number
US08003806B2

Reaction notes

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