Diethyl Ether → HCID 11594163, compound

HRID 1676034Notes

Reaction equation

HRID 1676034 reaction equation
[N:1]1([C@@H:10]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH2:11][C:12]([O:14]C(C)(C)C)=[O:13])[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[CH:2]1.C(OCC)C>Cl>[N:1]1([C@@H:10]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH2:11][C:12]([OH:14])=[O:13])[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[CH:2]1

Participants

4

Reactant 2

HCID 3283Diethyl EtherHCID 67354345HCID 67354345, compound

Product 1

HCID 11594163HCID 11594163, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A solution of tert-butyl (3R)-3-(1H-benzimidazol-1-yl)-3-phenylpropanoate (92 mg, 285 μmol) in hydrochloric acid (20 mL of a 5N solution) was stirred at room temperature for 48 hours. The solution was then evaporated in vacuo to give a gum. Trituration of this residue with diethyl ether afforded the title compound, [LCMS (Method B, Mobile Phase I) RT=3.45 min, MH+ 267].

Workup

  1. customThe solution was then evaporated in vacuo
  2. customto give a gum

Sources & evidence

ORD record
ord-deeb7520a8ad410da5447daaaee99086
Source dataset
uspto-grants-2011_08
Patent number
US08003806B2

Reaction notes

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