HCID 58653632, compound → HCID 11511224, compound

HRID 1676040Notes

Reaction equation

HRID 1676040 reaction equation
[C:1]1([CH:7]([N:13]2[C:17]3[CH:18]=[CH:19][CH:20]=[C:21]([N:22]4[CH2:27][CH2:26][CH:25]([C:28]([NH:30][C:31]5[NH:32][CH2:33][CH2:34][CH2:35][N:36]=5)=[O:29])[CH2:24][CH2:23]4)[C:16]=3[N:15]=[CH:14]2)[CH2:8][C:9]([O:11]C)=[O:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>Cl>[C:1]1([CH:7]([N:13]2[C:17]3[CH:18]=[CH:19][CH:20]=[C:21]([N:22]4[CH2:27][CH2:26][CH:25]([C:28]([NH:30][C:31]5[NH:32][CH2:33][CH2:34][CH2:35][N:36]=5)=[O:29])[CH2:24][CH2:23]4)[C:16]=3[N:15]=[CH:14]2)[CH2:8][C:9]([OH:11])=[O:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 1

HCID 58653632HCID 58653632, compound

Product 1

HCID 11511224HCID 11511224, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A solution of methyl 3-phenyl-3-(4-{4-[(1,4,5,6-tetrahydro-2-pyrimidinylamino)carbonyl]-1-piperidinyl}-1H-benzimidazol-1-yl)propanoate (17 mg, 24 μmol) in hydrochloric acid (10 mL of a 5N solution) was stirred at room temperature for 48 hours. The solution was evaporated in vacuo, and the residue purified by RP-HPLC to afford the title compound, [LCMS (Method A, Mobile Phase II) RT=3.5 min, MH+ 475].

Workup

  1. customThe solution was evaporated in vacuo
  2. customthe residue purified by RP-HPLC

Sources & evidence

ORD record
ord-33ad9f132e3b4a46b31881066cea25e5
Source dataset
uspto-grants-2011_08
Patent number
US08003806B2

Reaction notes

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