HCID 178470878, compound → HCID 178512493, compound

HRID 1676050Notes

Reaction equation

HRID 1676050 reaction equation
[NH2:1][C:2]([NH:4][C:5]1[CH:6]=[C:7]([CH:33]=[CH:34][CH:35]=1)[C:8]([NH:10][C:11]1[CH:32]=[CH:31][C:14]2[N:15]([CH:18]([C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)[CH2:19][C:20]([O:22]CC)=[O:21])[CH:16]=[N:17][C:13]=2[CH:12]=1)=[O:9])=[NH:3]>Cl>[NH2:3][C:2]([NH:4][C:5]1[CH:6]=[C:7]([CH:33]=[CH:34][CH:35]=1)[C:8]([NH:10][C:11]1[CH:32]=[CH:31][C:14]2[N:15]([CH:18]([C:25]3[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=3)[CH2:19][C:20]([OH:22])=[O:21])[CH:16]=[N:17][C:13]=2[CH:12]=1)=[O:9])=[NH:1]

Participants

3

Reactant 1

HCID 178470878HCID 178470878, compound

Product 1

HCID 178512493HCID 178512493, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A solution of ethyl 3-{5-[(3-{[amino(imino)methyl]amino}benzoyl)amino]-1H-benzimidazol-1-yl}-3-phenylpropanoate (32 mg, 68 μmol) in hydrochloric acid (20 mL of a 5N solution) was stirred at room temperature for 96 hours. The solution was evaporated in vacuo and the residue was purified by RP-HPLC to afford the title compound, [LCMS (Method A, Mobile Phase II) RT=2.99 min, MH+ 443].

Workup

  1. customThe solution was evaporated in vacuo
  2. customthe residue was purified by RP-HPLC

Sources & evidence

ORD record
ord-dd77218bd2684ba491dd8fb10172ae62
Source dataset
uspto-grants-2011_08
Patent number
US08003806B2

Reaction notes

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