HCID 178470877, compound → HCID 178512523, compound

HRID 1676061Notes

Reaction equation

HRID 1676061 reaction equation
[NH2:1][C:2]([NH:4][C:5]1[CH:35]=[CH:34][C:8]([C:9]([NH:11][C:12]2[CH:13]=[CH:14][C:15]3[N:19]=[CH:18][N:17]([CH:20]([C:27]4[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=4)[CH2:21][C:22]([O:24]CC)=[O:23])[C:16]=3[CH:33]=2)=[O:10])=[CH:7][CH:6]=1)=[NH:3]>Cl>[NH2:3][C:2]([NH:4][C:5]1[CH:6]=[CH:7][C:8]([C:9]([NH:11][C:12]2[CH:13]=[CH:14][C:15]3[N:19]=[CH:18][N:17]([CH:20]([C:27]4[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=4)[CH2:21][C:22]([OH:24])=[O:23])[C:16]=3[CH:33]=2)=[O:10])=[CH:34][CH:35]=1)=[NH:1]

Participants

3

Reactant 1

HCID 178470877HCID 178470877, compound

Product 1

HCID 178512523HCID 178512523, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A solution of ethyl 3-{6-[(4-{[amino(imino)methyl]amino}benzoyl)amino]-1H-benzimidazol-1-yl}-3-phenylpropanoate (15 mg, 32 μmol) in hydrochloric acid (20 mL of a 5N solution) was stirred at room temperature for 96 hours. The solution was then evaporated in vacuo, and the residue was purified by RP-HPLC to afford the title compound, [LCMS (Method A, Mobile Phase II) RT=2.86 min, MH+ 443].

Workup

  1. customThe solution was then evaporated in vacuo
  2. customthe residue was purified by RP-HPLC

Sources & evidence

ORD record
ord-7e8bfd9698ab4630b157cac535e827ea
Source dataset
uspto-grants-2011_08
Patent number
US08003806B2

Reaction notes

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