Acetonitrile → HCID 11688159, compound

HRID 1676091Notes

Reaction equation

HRID 1676091 reaction equation
C([O:3][C:4](=[O:25])[CH2:5][CH:6]([N:13]1[C:17]2[CH:18]=[CH:19][C:20]([C:22]([OH:24])=[O:23])=[CH:21][C:16]=2[N:15]=[CH:14]1)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)C.C(#N)C>Cl>[C:4]([CH2:5][CH:6]([N:13]1[C:17]2[CH:18]=[CH:19][C:20]([C:22]([OH:24])=[O:23])=[CH:21][C:16]=2[N:15]=[CH:14]1)[C:7]1[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=1)([OH:25])=[O:3]

Participants

4

Reactant 2

HCID 6342AcetonitrileHCID 58653638HCID 58653638, compound

Product 1

HCID 11688159HCID 11688159, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A solution of 1-(3-ethoxy-3-oxo-1-phenylpropyl)-1H-benzimidazole-5-carboxylic acid (40 mg, 118 μmol) in a mixture of hydrochloric acid (10 mL of a 5N solution) and acetonitrile (6 mL) was stirred at room temperature for 72 hours. The solution was evaporated in vacuo to afford the title compound, [LCMS (Method A, Mobile Phase I) RT=5.26 min, MH+ 311].

Workup

  1. customThe solution was evaporated in vacuo

Sources & evidence

ORD record
ord-a2947b86450c4a7cb0cc4277d92afdc6
Source dataset
uspto-grants-2011_08
Patent number
US08003806B2

Reaction notes

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