反应详情

LiOH (1.3 mL, 1.3 mmol, 1.0 M) was added to a solution of methyl 1-methyl-2-oxo-1,2-dihydropyridine-3-carboxylate (0.11 g, 0.65 mmol) in a mixture of THF-MeOH (3:1 ratio, 8 mL) at room temperature. After stirring for 2 hours, 1 N HCl (1.3 mL) was added. The reaction mixture was extracted with EtOAc, dried over MgSO4, and concentrated to give the desired product (0.044 g, 44% for 2 step process). 1H NMR (400 MHz, CD3OD) δ 8.45 (dd, 1H), 8.06 (dd, 1H), 6.66 (t, 1H), 3.71 (s, 3H).

1. extractionThe reaction mixture was extracted with EtOAc
2. dry with materialdried over MgSO4
3. concentrationconcentrated