HRID1676411

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

HCID14798

Sodium Hydroxide

HNaO

结构：CCOC(=O)c1cccnc1Nc1ccc(Oc2ccnc3cc(C4CCN(C(=O)OC(C)(C)C)CC4)sc23)c(F)c1

HCID67345485

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)N1CCC(c2cc3nccc(Oc4ccc(Nc5ncccc5C(=O)O)cc4F)c3s2)CC1

HCID67348510

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8028

Tetrahydrofuran

C4H8O

PROCEDURE

实验过程

A round-bottomed flask was charged with ethyl 2-(4-(2-(1-(tert-butoxycarbonyl)piperidin-4-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenylamino)nicotinate (0.100 g, 0.169 mmol) and THF (1 mL). NaOH (3.0 mL, 1N) was added and the mixture stirred for 1 hour. The mixture was then acidified to pH 6 with HCl aq. (1N) and extracted with EtOAc. The organics were dried (MgSO4), filtered and concentrated to get product as a yellow solid. LRMS (esi+) 565 m/z (M+1) detected.

WORKUP

后处理

extractionextracted with EtOAc
dry with materialThe organics were dried (MgSO4)
filtrationfiltered
concentrationconcentrated
customto get product as a yellow solid

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-316f2e0fbc2f4b8faafa63954fc5c86f
来源数据集: uspto-grants-2011_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08003662B2
来源说明: uspto-grants-2011_08

反应 SMILES

[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([C:14]2[S:22][C:21]3[C:16](=[N:17][CH:18]=[CH:19][C:20]=3[O:23][C:24]3[CH:29]=[CH:28][C:27]([NH:30][C:31]4[N:41]=[CH:40][CH:39]=[CH:38][C:32]=4[C:33]([O:35]CC)=[O:34])=[CH:26][C:25]=3[F:42])[CH:15]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[OH-].[Na+].Cl>C1COCC1>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([C:14]2[S:22][C:21]3[C:16](=[N:17][CH:18]=[CH:19][C:20]=3[O:23][C:24]3[CH:29]=[CH:28][C:27]([NH:30][C:31]4[N:41]=[CH:40][CH:39]=[CH:38][C:32]=4[C:33]([OH:35])=[O:34])=[CH:26][C:25]=3[F:42])[CH:15]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]