HRID1676930

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：NS(=O)(=O)c1cc(C(=O)O)c(NCc2ccco2)cc1Cl

HCID3440

Furosemide

C12H11ClN2O5S

HCID7503

Benzyl chloride

C7H7Cl

PRODUCTS

生成物

结构：NS(=O)(=O)c1cc(C(=O)OCc2ccccc2)c(NCc2ccco2)cc1Cl

HCID11697463

Phenylmethyl 5-(aminosulfonyl)-4-chloro-2-[(2-furanylmethyl)amino]benzoate

C19H17ClN2O5S

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

In a similar manner to Example 3, furosemide can be reacted with benzyl chloride in DMF to yield benzyl 5-aminosulfonyl-4-chloro-2-[(2-furanylmethyl)amino]benzoate.