Morpholine → HCID 10472353, compound

HRID 1676987Notes

Reaction equation

HRID 1676987 reaction equation
ClC1C=C2C(=CC=1)[N:7](S(C1C=CC=CC=1)(=O)=O)[C:6]([C:20]([O:22][CH2:23][CH3:24])=O)=C2S(Cl)(=O)=O.Cl[S:30]([C:33]1[C:41]2[C:36](=[CH:37][CH:38]=[C:39]([O:42][CH3:43])[CH:40]=2)[N:35](S(C2C=CC=CC=2)(=O)=O)[C:34]=1[C:53]([O:55]CC)=O)(=[O:32])=[O:31].Cl.CN.[NH:61]1CCOCC1>C(N(CC)CC)C>[CH3:43][O:42][C:39]1[CH:40]=[C:41]2[C:36](=[CH:37][CH:38]=1)[NH:35][C:34]([C:53]([NH2:61])=[O:55])=[C:33]2[S:30]([N:7]1[CH2:6][CH2:20][O:22][CH2:23][CH2:24]1)(=[O:31])=[O:32]

Participants

6

Reactant 4

HCID 8083MorpholineHCID 6364545Methylamine hydrochlorideHCID 22401482ethyl 5-chloro-3-(chlorosulfonyl)-1-(phenylsulfonyl)-1H-indole-2-carboxylateHCID 86601813HCID 86601813, compound

Product 1

HCID 10472353HCID 10472353, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

Following the procedures described in Steps D and E of Example 1, replacing in Step D ethyl 5-chloro-3-(chlorosulfonyl)-1-(phenylsulfonyl)-1H-indole-2-carboxylate with ethyl 3-(chlorosulfonyl)-5-methoxy-1-(phenylsulfonyl)-1H-indole-2-carboxylate, and methylamine hydrochloride and triethylamine with morpholine, the title compound was obtained. HRMS (ES) exact mass calculated for C14H18N3O5S (M+H+): 340.0962. Found 340.0960.

Sources & evidence

ORD record
ord-8bc8b52537384ec7bd96b4627b4ad87c
Source dataset
uspto-grants-2011_08
Patent number
US08008295B2

Reaction notes

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