Triethylamine → HCID 67372248, compound

HRID 1677011Notes

Reaction equation

HRID 1677011 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([S:11]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)(=[O:13])=[O:12])[C:6]([C:20]([O:22][CH2:23][CH3:24])=[O:21])=[C:5]2[S:25]([NH:28][CH2:29][CH2:30][NH:31][C:32]1[CH:37]=[CH:36][C:35]([O:38][CH3:39])=[CH:34][CH:33]=1)(=[O:27])=[O:26].[CH3:40][S:41](Cl)(=[O:43])=[O:42].C(N(CC)CC)C>ClCCl.CCOC(C)=O>[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([S:11]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)(=[O:12])=[O:13])[C:6]([C:20]([O:22][CH2:23][CH3:24])=[O:21])=[C:5]2[S:25]([NH:28][CH2:29][CH2:30][N:31]([C:32]1[CH:33]=[CH:34][C:35]([O:38][CH3:39])=[CH:36][CH:37]=1)[S:41]([CH3:40])(=[O:43])=[O:42])(=[O:26])=[O:27]

Participants

6

Reactant 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 67372260HCID 67372260, compound

Product 1

HCID 67372248HCID 67372248, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 8857Ethyl AcetateSolvent

Procedure

The material from Example 96, Step C was combined with methanesulfonyl chloride (1.1 equivalents) and triethylamine (3 equivalents) in dichloromethane, and stirred for for one hour at room temperature. The reaction was diluted with EtOAc, washed with sat NaHCO3 and brine, dried over Na2SO4 and concentrated in vacuo to obtain the titled compound. ESI+ MS: 714 [M+H]+.

Workup

  1. washwashed
  2. dry with materialdried over Na2SO4
  3. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-5486ea82fb464465a60527f8a693e2e6
Source dataset
uspto-grants-2011_08
Patent number
US08008295B2

Reaction notes

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