HCID 67371255, compound → HCID 67372881, compound

HRID 1677089Notes

Reaction equation

HRID 1677089 reaction equation
C([N:8]1[C@H:12]([C:13]2[CH:18]=[C:17]([F:19])[C:16]([F:20])=[C:15]([F:21])[CH:14]=2)[CH2:11][CH2:10][C@@H:9]1[C:22]1([OH:25])[CH2:24][CH2:23]1)C1C=CC=CC=1>[OH-].[OH-].[Pd+2].C(O)C>[F:19][C:17]1[CH:18]=[C:13]([C@H:12]2[NH:8][C@@H:9]([C:22]3([OH:25])[CH2:23][CH2:24]3)[CH2:10][CH2:11]2)[CH:14]=[C:15]([F:21])[C:16]=1[F:20]

Participants

4

Reactant 1

HCID 67371255HCID 67371255, compound

Product 1

HCID 67372881HCID 67372881, compoundYield 99%

Reagents, catalysts & solvents 2

HCID 9942167Palladium hydroxideCatalystHCID 702EthanolSolvent

Procedure

20% palladium hydroxide on carbon (100 mg, 50% water contain) was added to an ethanol (7 mL) solution of 1-[(2R,5S)-1-benzyl-5-(3,4,5-trifluorophenyl)pyrrolidine-2-yl]cyclopropanol (600 mg). Under a hydrogen atmosphere, stirring was continued for 3 hours. The resultant was filtered on celite, and by removing the solvent under a vacuum, the title compound (440 mg) was obtained. The physical property values are as follows.

Workup

  1. filtrationThe resultant was filtered on celite
  2. customby removing the solvent under a vacuum

Sources & evidence

ORD record
ord-23809de27fb14a16b19004e60eeb8ef9
Source dataset
uspto-grants-2011_08
Patent number
US08008293B2

Reaction notes

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