1-Methylpiperazine → HCID 57571698, compound

HRID 1677109Notes

Reaction equation

HRID 1677109 reaction equation
Cl[C:2]1[CH:11]=[C:10]([C:12]([F:15])([F:14])[F:13])[C:5]([C:6]([O:8]C)=O)=[CH:4][N:3]=1.[CH3:16][N:17]1[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]1.[Cl:23][C:24]1[CH:32]=[CH:31][C:27]([CH2:28][CH2:29][NH2:30])=[CH:26][CH:25]=1>>[Cl:23][C:24]1[CH:32]=[CH:31][C:27]([CH2:28][CH2:29][NH:30][C:6](=[O:8])[C:5]2[C:10]([C:12]([F:15])([F:14])[F:13])=[CH:11][C:2]([N:20]3[CH2:21][CH2:22][N:17]([CH3:16])[CH2:18][CH2:19]3)=[N:3][CH:4]=2)=[CH:26][CH:25]=1

Participants

4

Reactant 3

HCID 531671-MethylpiperazineHCID 674302-(4-Chlorophenyl)ethylamineHCID 2775340Methyl 6-chloro-4-(trifluoromethyl)nicotinate

Product 1

HCID 57571698HCID 57571698, compound

Procedure

In analogy to example 1 methyl 6-chloro-4-(trifluoromethyl)nicotinate was reacted with N-methylpiperazine and then, using 4-chlorophenethylamine in the coupling step, converted to N-[2-(4-chloro-phenyl)-ethyl]-6-(4-methyl-piperazin-1-yl)-4-trifluoro-methyl-nicotinamide. Off-white solid. MS (ISP): 427.2 ([M+H]+)

Sources & evidence

ORD record
ord-483ecd1767654629a8a7c51d2431efd5
Source dataset
uspto-grants-2011_08
Patent number
US08008305B2

Reaction notes

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