反应详情

Procedure X′: To a stirring solution of 4-bromobenzoic acid-2,5-dioxo-pyrrolidin-1-yl ester (3.5 g, 11.7 mmol), [which can be prepared from 4-bromobenzoic acid and N-hydroxy succinamide by the method of C. Mitsos, Chem Pharm Bull 48(2), 211-214 (2000), or purchased from Ambinter, CAS#80586-82-9], in tetrahydrofuran (0.15M), add (S)-(+)-1-(2-pyrrolidinylmethyl)pyrrolidine and heat to reflux for four hours. After this time, remove the heat and wash the reaction with water while extracting with 10% isopropanol/dichloromethane. Dry the organics with sodium sulfate, filter and concentrate in vacuo. Purify on a silica column eluting with 2M ammonia in methanol and dichloromethane to give (4-bromo-phenyl)-(2-(S)-pyrrolidin-1-ylmethyl-pyrrolidin-yl)methanone (93% yield with 80% purity). MS (m/e): 337.1 (M+1)

1. temperatureheat
2. temperatureto reflux for four hours
3. customAfter this time, remove the
4. temperatureheat
5. washwash
6. customthe reaction with water
7. extractionwhile extracting with 10% isopropanol/dichloromethane
8. dry with materialDry the organics with sodium sulfate
9. filtrationfilter
10. concentrationconcentrate in vacuo
11. customPurify on a silica column
12. washeluting with 2M ammonia in methanol and dichloromethane