Trifluoroacetic acid → HCID 59322874, compound

HRID 1677231Notes

Reaction equation

HRID 1677231 reaction equation
C(OC(=O)[NH:7][CH2:8][CH2:9][N:10]([CH2:12][CH2:13][N:14]1[C:23](=[O:24])[C:22]2[CH:25]=[CH:26][C:27]([O:28][CH3:29])=[C:20]3[C:21]=2[C:16](=[C:17]2[CH:33]=[CH:32][CH:31]=[CH:30][C:18]2=[CH:19]3)[C:15]1=[O:34])[CH3:11])(C)(C)C.FC(F)(F)C(O)=O>C(Cl)Cl>[NH2:7][CH2:8][CH2:9][N:10]([CH3:11])[CH2:12][CH2:13][N:14]1[C:23](=[O:24])[C:22]2[CH:25]=[CH:26][C:27]([O:28][CH3:29])=[C:20]3[C:21]=2[C:16](=[C:17]2[CH:33]=[CH:32][CH:31]=[CH:30][C:18]2=[CH:19]3)[C:15]1=[O:34]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 59322871HCID 59322871, compound

Product 1

HCID 59322874HCID 59322874, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Method (ii)—Removing Boc protection by Preparing Trifluoroacetic salt: The trifluoroacetic salt of 2-{2-[(2-aminoethyl)methylamino]ethyl}-6-methoxy-1,2-dihydro-3H-dibenzo[de,h]isoquinoline-1,3-dione was prepared by stirring (2-{[2-(6-Methoxy-1,3-dioxo-1H,3H-dibenzo[de,h]isoquinolin-2-yl)-ethyl]-methyl-amino}-ethyl)-carbamic acid tert-butyl ester with 50% trifluoroacetic acid in DCM for 40 minutes. The reaction was quantitative.

Workup

  1. customMethod (ii)—Removing Boc protection by Preparing Trifluoroacetic salt

Sources & evidence

ORD record
ord-70e2ff1592344c58a7b3fb8b5004e893
Source dataset
uspto-grants-2011_08
Patent number
US08008316B2

Reaction notes

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