Hydrazine hydrate (1:1) → HCID 178509212, compound

HRID 1677634Notes

Reaction equation

HRID 1677634 reaction equation
[OH:1][C:2]1[N:9]=[CH:8][CH:7]=[C:6](OC)[C:3]=1[C:4]#[N:5].O.[NH2:13][NH2:14]>>[NH2:5][C:4]1[C:3]2[C:2]([OH:1])=[N:9][CH:8]=[CH:7][C:6]=2[NH:14][N:13]=1

Participants

3

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 178493245HCID 178493245, compound

Product 1

HCID 178509212HCID 178509212, compound

Conditions

Temperature
140 °C

Procedure

A mixture of 1.2 g of 2-hydroxy-4-methoxynicotinonitrile and 30 mL of hydrazine hydrate is maintained at 140° C. for 18 hours in a bomb. The reaction medium is then evaporated to dryness. The residue is taken up in ethyl ether, and the resulting suspension is filtered. 1.1 g of 3-amino-1H-pyrazolo[4,3-c]pyrid-4-ol are obtained in the form of a grey solid.

Workup

  1. customThe reaction medium is then evaporated to dryness
  2. filtrationthe resulting suspension is filtered

Sources & evidence

ORD record
ord-281f9f25c49a4228b31eb5f97cee0eb1
Source dataset
uspto-grants-2011_08
Patent number
US08008322B2

Reaction notes

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