Hydrochloric Acid → HCID 67373446, compound

HRID 1677809Notes

Reaction equation

HRID 1677809 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8][C:9]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[NH:11][C:10]=1[C:18]([N:20]1[CH2:24][CH2:23][CH2:22][CH2:21]1)=[O:19].[ClH:25]>CCOCC>[ClH:25].[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8][C:9]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[NH:11][C:10]=1[C:18]([N:20]1[CH2:24][CH2:23][CH2:22][CH2:21]1)=[O:19]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 11595234HCID 11595234, compound

Product 1

HCID 67373446HCID 67373446, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Stir [3-(2-amino-phenylsulfanyl)-1H-indol-2-yl]-pyrrolidin-1-yl-methanone (Iz, 60 mg) in Et2O (5 mL) with 1N HCl (1 mL) and collect the precipitate by filtration. Wash the filter cake with Et2O and dry to afford the title compound Iaa (48 mg) as a white solid, mp 154-155° C.; m/z=338 (M+1)

Workup

  1. customcollect the precipitate
  2. filtrationby filtration
  3. washWash the filter cake with Et2O
  4. customdry

Sources & evidence

ORD record
ord-1a2ef2de562e4cd296d04acd98252ae0
Source dataset
uspto-grants-2011_08
Patent number
US08008340B2

Reaction notes

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