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HRID1677956

反应详情

EQUATION

反应方程式

HRID 1677956 的结构方程式

REACTANTS

反应物

4
结构：c1ccc(P(c2ccccc2)c2ccccc2)cc1
HCID11776

Triphenylphosphine

C18H15P

结构：CCOC(=O)N=NC(=O)OCC
HCID220568

Diethyl azodicarboxylate

C6H10N2O4

结构：CO[C@H]1Cc2ccccc2[C@H]1Nc1cc(O[C@@H]2C[C@@H](CO)[C@@H](O[Si](C)(C)C(C)(C)C)C2)ncn1
HCID66797929

未命名化合物

结构：CC(C)(C)OC(=O)N[SH](=O)=O
HCID178454374

未命名化合物

PRODUCTS

生成物

1
结构：CO[C@H]1Cc2ccccc2[C@H]1Nc1cc(O[C@@H]2C[C@@H](CN(C(=O)OC(C)(C)C)S(N)(=O)=O)[C@@H](O[Si](C)(C)C(C)(C)C)C2)ncn1
HCID66797969

未命名化合物

收率 94%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCOC(C)=O
溶剂HCID8857

Ethyl acetate

C4H8O2

PROCEDURE

实验过程

To a solution of {(1S,2S,4R)-2-{[tert-butyl(dimethyl)silyl]oxy}-4-[(6-{[(1R,2S)-2-methoxy-2,3-dihydro-1H-inden-1-yl]amino}pyrimidin-4-yl)oxy]cyclopentyl}methanol (105.3 mg, 0.0002168 mol), N-Boc-sulfonamide (58.9 mg, 0.000300 mol) and triphenylphosphine (85.3 mg, 0.000325 mol) in EtOAc (4.15 mL) under an atmosphere of nitrogen was added diethyl azodicarboxylate (51.9 μL, 0.000330 mol). The mixture was stirred for four hours. The solvent was removed and the orange residue was purified by flash chromatography (10 to 50% EtOAc/hexanes) to obtain 135.2 mg (94%) of the title compound.

WORKUP

后处理

  1. customThe solvent was removed
  2. customthe orange residue was purified by flash chromatography (10 to 50% EtOAc/hexanes)