Tetrahydrofuran → tert-Butyl 4-cyanopiperazine-1-carboxylate

HRID 167800Notes

Reaction equation

HRID 167800 reaction equation
[CH2:24]1[O:25][CH2:26][CH2:27][CH2:28]1.[CH3:14][CH2:15][N:16]([CH2:17][CH3:18])[CH2:19][CH3:20].[N:1]1([C:7](=[O:8])[O:9][C:10]([CH3:11])([CH3:12])[CH3:13])[CH2:2][CH2:3][NH:4][CH2:5][CH2:6]1.[N:21]#[C:22][Br:23]>>[N:1]1([C:7](=[O:8])[O:9][C:10]([CH3:11])([CH3:12])[CH3:13])[CH2:2][CH2:3][N:4]([C:15]#[N:16])[CH2:5][CH2:6]1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 8471TriethylamineHCID 10476Cyanogen BromideHCID 143452tert-Butyl piperazine-1-carboxylate

Product 1

HCID 14068968tert-Butyl 4-cyanopiperazine-1-carboxylate

Sources & evidence

ORD record
ord-9d4abe247b1348368f917bef18fd9eb1
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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