反应详情

A mixture of 4,5-dichlorothieno[2,3-d]pyrimidine (prepared as taught in EP 447,891) (775 mg, 3.8 mmol), 1-(4-isopropylphenyl)ethanamine (compound 95) (734 mg, 4.5 mmol), and triethylamine (767 mg, 7.6 mmol) in DMF (20 mL) was allowed to react for 24 hours at 20° C. The reaction mixture was diluted with water and extracted thrice with Et2O. The organic portions were combined, washed with brine, and dried (Na2SO4). The mixture was filtered through silica gel, and the solvent was removed in vacuo. The residue was purified by flash chromatography (15 percent Et2O in pentane), yielding 1.1 g of oil.

1. customto react for 24 hours at 20° C
2. extractionextracted thrice with Et2O
3. washwashed with brine
4. dry with materialdried (Na2SO4)
5. filtrationThe mixture was filtered through silica gel
6. customthe solvent was removed in vacuo
7. customThe residue was purified by flash chromatography (15 percent Et2O in pentane)