Water → HCID 67375114, compound
Reaction equation
Br[CH2:2][CH2:3][CH2:4][CH2:5][Cl:6].[C:7]([C:9]1[C:10](=[O:16])[NH:11][C:12](=[O:15])[NH:13][CH:14]=1)#[N:8].C([O-])([O-])=O.[K+].[K+].O>CS(C)=O.CN(C)C=O>[Cl:6][CH2:5][CH2:4][CH2:3][CH2:2][N:13]1[CH:14]=[C:9]([C:7]#[N:8])[C:10](=[O:16])[NH:11][C:12]1=[O:15]Participants
Reactant 4
Product 1
Reagents, catalysts & solvents 2
Conditions
- Temperature
- 20 °C
Procedure
2.6 g (15.0 mmol) of 1-bromo-4-chlorobutane were added dropwise to a solution of 2.06 g (15.0 mmol) of 5-cyanouracil in 50 ml of dimethyl sulfoxide (DMSO) and 20.0 ml of N,N-dimethylformamide (DMF) at 0° C., and 2.07 g (15.0 mmol) of K2CO3 were added in portions over the course of 1 hour. The mixture was then stirred at 20° C. for 10 minutes (dialkylated product already identifiable). Water was added to the reaction mixture, and then the aqueous mixture was extracted twice with diethyl ether and twice with methylene chloride. The aqueous phase was adjusted to pH 3-4 and then extracted with methylene chloride. The methylene chloride phase was then dried, the desiccant was removed by filtration, and the solvent was evaporated to dryness in vacuo; yield: 0.6 g. 1-(4-Chlorobutyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile was employed without further purification in the next step.
Workup
- extractionthe aqueous mixture was extracted twice with diethyl ether and twice with methylene chloride
- extractionextracted with methylene chloride
- dry with materialThe methylene chloride phase was then dried
- customthe desiccant was removed by filtration
- customthe solvent was evaporated to dryness in vacuo
- custom1-(4-Chlorobutyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile was employed without further purification in the next step
Sources & evidence
- ORD record
- ord-a87451cf80764b888f83d0fea1470f3a
- Source dataset
- uspto-grants-2011_08
- Patent number
- US08008488B2
Reaction notes
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