Piperazine → 2-(piperazin-1-yl)-1-(pyridin-3-yl)-1H-indole-3-carboxaldehyde

HRID 1678131Notes

Reaction equation

HRID 1678131 reaction equation
Cl[CH:2]1[CH:10]([CH:11]=[O:12])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]1[C:13]1[CH:14]=[N:15][CH:16]=[CH:17][CH:18]=1.[NH:19]1[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1>>[N:19]1([C:2]2[N:3]([C:13]3[CH:14]=[N:15][CH:16]=[CH:17][CH:18]=3)[C:4]3[C:9]([C:10]=2[CH:11]=[O:12])=[CH:8][CH:7]=[CH:6][CH:5]=3)[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1

Participants

3

Reactant 2

HCID 4837PiperazineHCID 86035953HCID 86035953, compound

Product 1

HCID 112897502-(piperazin-1-yl)-1-(pyridin-3-yl)-1H-indole-3-carboxaldehydeYield 23%

Procedure

2-chloro-1-(pyridin-3-yl)-1,3-dihydroindole-3-carboxaldehyde is reacted with piperazine as described in Example 2 to give, after flash chromatography, the title compound (23% yield).

Workup

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Sources & evidence

ORD record
ord-69d6fb9fff614268a05ba73e674956ce
Source dataset
uspto-grants-2011_08
Patent number
US08008491B2

Reaction notes

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