Tetrahydrofuran → HCID 68257805, compound

HRID 1678462Notes

Reaction equation

HRID 1678462 reaction equation
C[O:2][C:3]([C:5]1[CH:6]=[C:7]([C:12]2[CH:17]=[CH:16][C:15]([C:18](=[O:35])[NH:19][C:20]3[CH:25]=[CH:24][C:23]([CH2:26][N:27]4[CH2:32][CH2:31][S:30](=[O:34])(=[O:33])[CH2:29][CH2:28]4)=[CH:22][CH:21]=3)=[CH:14][CH:13]=2)[C:8]([CH3:11])=[CH:9][CH:10]=1)=[O:4].C1COCC1>[OH-].[Na+]>[O:34]=[S:30]1(=[O:33])[CH2:31][CH2:32][N:27]([CH2:26][C:23]2[CH:24]=[CH:25][C:20]([NH:19][C:18]([C:15]3[CH:14]=[CH:13][C:12]([C:7]4[C:8]([CH3:11])=[CH:9][CH:10]=[C:5]([C:3]([OH:4])=[O:2])[CH:6]=4)=[CH:17][CH:16]=3)=[O:35])=[CH:21][CH:22]=2)[CH2:28][CH2:29]1

Participants

4

Reactant 2

HCID 8028TetrahydrofuranHCID 68257806HCID 68257806, compound

Product 1

HCID 68257805HCID 68257805, compound

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

4′-[4-(1,1-Dioxo-1lambda*6*-thiomorpholin-4-ylmethyl)-phenylcarbamoyl]-6-methyl-biphenyl-3-carboxylic acid methyl ester (1.09 g) was heated to reflux in 1M sodium hydroxide (20 ml) and THF (20 ml) for 3 h. The mixture was then allowed to cool, and the THF evaporated. The aqueous residue was extracted with dichloromethane, and was then acidified. The resultant white solid was collected by filtration and dried (950 mg).

Workup

  1. temperatureto cool
  2. customthe THF evaporated
  3. extractionThe aqueous residue was extracted with dichloromethane
  4. filtrationThe resultant white solid was collected by filtration
  5. customdried (950 mg)

Sources & evidence

ORD record
ord-59cb6f24581544c2b930ddf6042c4b6e
Source dataset
uspto-grants-2011_08
Patent number
US08008303B2

Reaction notes

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