Hydrochloric Acid → HCID 67372184, compound

HRID 1678481Notes

Reaction equation

HRID 1678481 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[CH:11]=[CH:10][C:9]([C:12]2[CH:17]=[C:16]([N+:18]([O-])=O)[CH:15]=[CH:14][C:13]=2[O:21][CH3:22])=[CH:8][CH:7]=1)=[O:5])[CH3:2].[ClH:23]>C(O)C>[ClH:23].[CH2:1]([O:3][C:4]([C:6]1[CH:11]=[CH:10][C:9]([C:12]2[CH:17]=[C:16]([NH2:18])[CH:15]=[CH:14][C:13]=2[O:21][CH3:22])=[CH:8][CH:7]=1)=[O:5])[CH3:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 59822345HCID 59822345, compound

Product 1

HCID 67372184HCID 67372184, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2′-Methoxy-5′-nitro-biphenyl-4-carboxylic acid ethyl ester (600 mg) in ethanol 90 ml) and 2M HCl (2.5 ml) was hydrogenated at RTP for 3 h. The mixture was then filtered through celite and the solvent evaporated. The dark solid residue was dissolved in 1:1 aqueous acetonitrile, filtered through celite again and evaporated giving the title compound as a red solid (595 mg).

Workup

  1. filtrationThe mixture was then filtered through celite
  2. customthe solvent evaporated
  3. dissolutionThe dark solid residue was dissolved in 1:1 aqueous acetonitrile
  4. filtrationfiltered through celite again
  5. customevaporated

Sources & evidence

ORD record
ord-feb8ef4fc93c402482a8997a727445df
Source dataset
uspto-grants-2011_08
Patent number
US08008303B2

Reaction notes

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