Hydrochloric Acid → HCID 13941271, compound

HRID 1678594Notes

Reaction equation

HRID 1678594 reaction equation
COC[O:4][C:5]1[CH:6]=[C:7]([CH2:18][OH:19])[CH:8]=[C:9]([O:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:10]=1.Cl>C(O)C>[OH:19][CH2:18][C:7]1[CH:6]=[C:5]([OH:4])[CH:10]=[C:9]([O:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:8]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 23136425HCID 23136425, compound

Product 1

HCID 13941271HCID 13941271, compoundYield 97%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
40 °C

Procedure

To a solution of [3-(methoxymethoxy)-5-phenoxyphenyl]methanol (0.75 g, 2.86 mmol) in ethanol (10 mL) was added concentrated hydrochloric acid (1 mL), and the mixture was stirred at 40° C. for 4 hours. The reaction solution was concentrated under reduced pressure, and the resulting residue was purified with silica gel column chromatography (hexane/ethyl acetate=5:5) to give the title compound (0.60 g, yield 96%) as an oily matter.

Workup

  1. concentrationThe reaction solution was concentrated under reduced pressure
  2. customthe resulting residue was purified with silica gel column chromatography (hexane/ethyl acetate=5:5)

Sources & evidence

ORD record
ord-c60c381003214b4687a19da3b0996ac2
Source dataset
uspto-grants-2011_08
Patent number
US08008525B2

Reaction notes

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