Lithium Hydroxide → 4-{2-[2-(4-Chloro-phenyl)-2H-indazol-3-yl]-2-cyclohexyl-acetylamino}-3-fluoro-benzoic acid

HRID 1678632Notes

Reaction equation

HRID 1678632 reaction equation
C([O:3][C:4](=[O:38])[C:5]1[CH:10]=[CH:9][C:8]([NH:11][C:12](=[O:36])[CH:13]([C:20]2[N:21]([C:29]3[CH:34]=[CH:33][C:32]([Cl:35])=[CH:31][CH:30]=3)[N:22]=[C:23]3[C:28]=2[CH:27]=[CH:26][CH:25]=[CH:24]3)[CH:14]2[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]2)=[C:7]([F:37])[CH:6]=1)C.[OH-].[Li+]>C1COCC1.CO>[Cl:35][C:32]1[CH:33]=[CH:34][C:29]([N:21]2[C:20]([CH:13]([CH:14]3[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]3)[C:12]([NH:11][C:8]3[CH:9]=[CH:10][C:5]([C:4]([OH:38])=[O:3])=[CH:6][C:7]=3[F:37])=[O:36])=[C:28]3[C:23]([CH:24]=[CH:25][CH:26]=[CH:27]3)=[N:22]2)=[CH:30][CH:31]=1

Participants

5

Reactant 2

HCID 3939Lithium HydroxideHCID 671311734-{2-[2-(4-Chloro-phenyl)-2H-indazol-3-yl]-2-cyclohexyl-acetylamino}-3-fluoro-benzoic acid ethyl ester

Product 1

HCID 451105164-{2-[2-(4-Chloro-phenyl)-2H-indazol-3-yl]-2-cyclohexyl-acetylamino}-3-fluoro-benzoic acid

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

In analogy to the procedure described in example 7.2, 4-{2-[2-(4-chloro-phenyl)-2H-indazol-3-yl]-2-cyclohexyl-acetylamino}-3-fluoro-benzoic acid ethyl ester was treated with 1 N aqueous lithium hydroxide solution in THF and MeOH to give the title compound as yellow oil. MS: m/e=506.2 [M+H+].

Sources & evidence

ORD record
ord-c0c834630580472c9a23bb36734d1fd5
Source dataset
uspto-grants-2011_08
Patent number
US08008505B2

Reaction notes

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