Triethylamine → HCID 67131068, compound

HRID 1678650Notes

Reaction equation

HRID 1678650 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:16]([C:17]([CH:19]3[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]3)=[O:18])=[C:15]3[C:10]([CH:11]=[C:12]([F:26])[C:13]([F:25])=[CH:14]3)=[N:9]2)=[CH:4][CH:3]=1.[CH3:27][Si:28](C#N)([CH3:30])[CH3:29].[CH2:33]([N:35](CC)CC)C>[I-].[Zn+2].[I-]>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[C:16]([C:17]([CH:19]3[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]3)([O:18][Si:28]([CH3:30])([CH3:29])[CH3:27])[C:33]#[N:35])=[C:15]3[C:10]([CH:11]=[C:12]([F:26])[C:13]([F:25])=[CH:14]3)=[N:9]2)=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 82115Trimethylsilyl cyanideHCID 67131133HCID 67131133, compound

Product 1

HCID 67131068HCID 67131068, compound

Reagents, catalysts & solvents 1

HCID 9883512zinc(II)iodideCatalyst

Procedure

In analogy to the procedure described in example 10.3, [2-(4-chloro-phenyl)-5,6-difluoro-2H-indazol-3-yl]-cyclohexyl-methanone was treated with trimethylsilyl cyanide and zinc(II) iodide in triethylamine to give the title compound as yellow solid. MS: m/e=474.2 [M+H+].

Sources & evidence

ORD record
ord-a61dcc83e4b64e898d39deaa6242d8fe
Source dataset
uspto-grants-2011_08
Patent number
US08008505B2

Reaction notes

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