Lithium Hydroxide → [Rac]-2-(4-{2-[2-(4-chloro-phenyl)-5,6-difluoro-2h-indazol-3-yl]-2-cyclohexyl-acetylamino}-3-fluoro-phenoxy)-2-methyl-propionic acid

HRID 1678655Notes

Reaction equation

HRID 1678655 reaction equation
C([O:3][C:4](=[O:44])[C:5]([O:8][C:9]1[CH:14]=[CH:13][C:12]([NH:15][C:16](=[O:42])[CH:17]([C:24]2[N:25]([C:35]3[CH:40]=[CH:39][C:38]([Cl:41])=[CH:37][CH:36]=3)[N:26]=[C:27]3[C:32]=2[CH:31]=[C:30]([F:33])[C:29]([F:34])=[CH:28]3)[CH:18]2[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]2)=[C:11]([F:43])[CH:10]=1)([CH3:7])[CH3:6])C.[OH-].[Li+]>C1COCC1.CO>[Cl:41][C:38]1[CH:39]=[CH:40][C:35]([N:25]2[C:24]([CH:17]([CH:18]3[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]3)[C:16]([NH:15][C:12]3[CH:13]=[CH:14][C:9]([O:8][C:5]([CH3:7])([CH3:6])[C:4]([OH:44])=[O:3])=[CH:10][C:11]=3[F:43])=[O:42])=[C:32]3[C:27]([CH:28]=[C:29]([F:34])[C:30]([F:33])=[CH:31]3)=[N:26]2)=[CH:36][CH:37]=1

Participants

5

Reactant 2

HCID 3939Lithium HydroxideHCID 45110917[Rac]-2-(4-{2-[2-(4-chloro-phenyl)-5,6-difluoro-2h-indazol-3-yl]-2-cyclohexyl-acetylamino}-3-fluoro-phenoxy)-2-methyl-propionic acid ethyl ester

Product 1

HCID 45110918[Rac]-2-(4-{2-[2-(4-chloro-phenyl)-5,6-difluoro-2h-indazol-3-yl]-2-cyclohexyl-acetylamino}-3-fluoro-phenoxy)-2-methyl-propionic acid

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

In analogy to the procedure described in example 7.2, [rac]-2-(4-{2-[2-(4-chloro-phenyl)-5,6-difluoro-2H-indazol-3-yl]-2-cyclohexyl-acetylamino}-3-fluoro-phenoxy)-2-methyl-propionic acid ethyl ester was treated with 1 N aqueous lithium hydroxide solution in THF and MeOH to give the title compound as red solid. MS: m/e=600.2 [M+H+].

Sources & evidence

ORD record
ord-c2258a0174fe4307932b73ab7ac5e81a
Source dataset
uspto-grants-2011_08
Patent number
US08008505B2

Reaction notes

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