Lithium Hydroxide → HCID 45111060, compound

HRID 1678664Notes

Reaction equation

HRID 1678664 reaction equation
C[O:2][C:3](=[O:38])[C:4]1[CH:9]=[C:8]([CH3:10])[C:7]([O:11][CH:12]([C:19]2[N:20]([C:30]3[CH:35]=[CH:34][C:33]([Cl:36])=[CH:32][CH:31]=3)[N:21]=[C:22]3[C:27]=2[CH:26]=[C:25]([F:28])[C:24]([F:29])=[CH:23]3)[CH:13]2[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]2)=[C:6]([CH3:37])[CH:5]=1.[OH-].[Li+]>C1COCC1.CO>[Cl:36][C:33]1[CH:34]=[CH:35][C:30]([N:20]2[C:19]([CH:12]([CH:13]3[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]3)[O:11][C:7]3[C:8]([CH3:10])=[CH:9][C:4]([C:3]([OH:38])=[O:2])=[CH:5][C:6]=3[CH3:37])=[C:27]3[C:22]([CH:23]=[C:24]([F:29])[C:25]([F:28])=[CH:26]3)=[N:21]2)=[CH:31][CH:32]=1

Participants

5

Reactant 2

HCID 3939Lithium HydroxideHCID 45111059HCID 45111059, compound

Product 1

HCID 45111060HCID 45111060, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

In analogy to the procedure described in example 7.2, [rac]-4-{[2-(4-chloro-phenyl)-5,6-difluoro-2H-indazol-3-yl]-cyclohexyl-methoxy}-3,5-dimethyl-benzoic acid methyl ester (example 33) was treated with 1 N aqueous lithium hydroxide solution in THF and MeOH to give the title compound as yellow foam. MS: m/e=523.3 [M−H−].

Sources & evidence

ORD record
ord-45153b4b60a846379d0b905e6728998c
Source dataset
uspto-grants-2011_08
Patent number
US08008505B2

Reaction notes

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