Triethylamine hydrochloride → HCID 45111211, compound

HRID 1678666Notes

Reaction equation

HRID 1678666 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:16]([CH:17]([CH:29]3[CH2:34][CH2:33][CH2:32][CH2:31][CH2:30]3)[CH2:18][O:19][C:20]3[CH:27]=[CH:26][C:23]([C:24]#[N:25])=[CH:22][C:21]=3[F:28])=[C:15]3[C:10]([CH:11]=[C:12]([F:36])[C:13]([F:35])=[CH:14]3)=[N:9]2)=[CH:4][CH:3]=1.[N-:37]=[N+:38]=[N-:39].[Na+].Cl.C(N(CC)CC)C>CN(C=O)C>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:16]([CH:17]([CH:29]3[CH2:30][CH2:31][CH2:32][CH2:33][CH2:34]3)[CH2:18][O:19][C:20]3[CH:27]=[CH:26][C:23]([C:24]4[N:37]=[N:38][NH:39][N:25]=4)=[CH:22][C:21]=3[F:28])=[C:15]3[C:10]([CH:11]=[C:12]([F:36])[C:13]([F:35])=[CH:14]3)=[N:9]2)=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 11130Triethylamine hydrochlorideHCID 33557Sodium AzideHCID 67131140HCID 67131140, compound

Product 1

HCID 45111211HCID 45111211, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

In analogy to the procedure described in example 31, [rac]-4-{2-[2-(4-Chloro-phenyl)-5,6-difluoro-2H-indazol-3-yl]-2-cyclohexyl-ethoxy}-3-fluoro-benzonitrile was reacted with sodium azide in the presence of triethylamine hydrochloride in DMF to obtain the title compound as colorless oil. MS: m/e=553.3 [M+H+].

Sources & evidence

ORD record
ord-28fdde4d18024268894abc5d34ef8751
Source dataset
uspto-grants-2011_08
Patent number
US08008505B2

Reaction notes

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