Triethylamine hydrochloride → HCID 45111366, compound

HRID 1678670Notes

Reaction equation

HRID 1678670 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:16]([C:17]([CH:29]3[CH2:34][CH2:33][CH2:32][CH2:31][CH2:30]3)([O:27][CH3:28])C3C=CC(C#N)=CC=3F)=[C:15]3[C:10]([CH:11]=[C:12]([F:36])[C:13]([F:35])=[CH:14]3)=[N:9]2)=[CH:4][CH:3]=1.[N-:37]=[N+:38]=[N-:39].[Na+].Cl.C([N:44]([CH2:47][CH3:48])CC)C>CN(C=O)C>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[C:16]([CH:17]([CH:29]3[CH2:30][CH2:31][CH2:32][CH2:33][CH2:34]3)[O:27][CH2:28][C:12]3[CH:11]=[CH:10][C:48]([C:47]4[N:37]=[N:38][NH:39][N:44]=4)=[CH:14][C:13]=3[F:35])=[C:15]3[C:10]([CH:11]=[C:12]([F:36])[C:13]([F:35])=[CH:14]3)=[N:9]2)=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 11130Triethylamine hydrochlorideHCID 33557Sodium AzideHCID 67131109HCID 67131109, compound

Product 1

HCID 45111366HCID 45111366, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

In analogy to the procedure described in example 31, [rac]-4-{[2-(4-chloro-phenyl)-5,6-difluoro-2H-indazol-3-yl]-cyclohexyl-methoxymethyl}-3-fluoro-benzonitrile (example 41) was reacted with sodium azide in the presence of triethylamine hydrochloride in DMF to obtain the title compound as yellow foam. MS: m/e=553.2 [M+H+].

Sources & evidence

ORD record
ord-05c3aa004ad7473099701230fe51e695
Source dataset
uspto-grants-2011_08
Patent number
US08008505B2

Reaction notes

Loading…