Lithium Hydroxide → HCID 45111367, compound

HRID 1678671Notes

Reaction equation

HRID 1678671 reaction equation
C[O:2][C:3](=[O:39])[C:4]1[CH:9]=[C:8]([CH3:10])[C:7]([O:11][CH2:12][CH:13]([C:20]2[N:21]([C:31]3[CH:36]=[CH:35][C:34]([Cl:37])=[CH:33][CH:32]=3)[N:22]=[C:23]3[C:28]=2[CH:27]=[C:26]([F:29])[C:25]([F:30])=[CH:24]3)[CH:14]2[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]2)=[C:6]([CH3:38])[CH:5]=1.[OH-].[Li+]>C1COCC1.CO>[Cl:37][C:34]1[CH:35]=[CH:36][C:31]([N:21]2[C:20]([CH:13]([CH:14]3[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]3)[CH2:12][O:11][C:7]3[C:6]([CH3:38])=[CH:5][C:4]([C:3]([OH:39])=[O:2])=[CH:9][C:8]=3[CH3:10])=[C:28]3[C:23]([CH:24]=[C:25]([F:30])[C:26]([F:29])=[CH:27]3)=[N:22]2)=[CH:32][CH:33]=1

Participants

5

Reactant 2

HCID 3939Lithium HydroxideHCID 67131136HCID 67131136, compound

Product 1

HCID 45111367HCID 45111367, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

In analogy to the procedure described in example 7.2, [rac]-4-{2-[2-(4-chloro-phenyl)-5,6-difluoro-2H-indazol-3-yl]-2-cyclohexyl-ethoxy}-3,5-dimethyl-benzoic acid methyl ester was treated with 1 N aqueous lithium hydroxide solution in THF and MeOH to give the title compound as off-white solid. MS: m/e=539.3 [M+H+].

Sources & evidence

ORD record
ord-85ff42d5ad8245b08af933fb5fef863e
Source dataset
uspto-grants-2011_08
Patent number
US08008505B2

Reaction notes

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