Triethylamine hydrochloride → HCID 45111519, compound

HRID 1678672Notes

Reaction equation

HRID 1678672 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:16]([C:17]([CH:28]3[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]3)([O:26][CH3:27])C3C=CC(C#N)=CC=3)=[C:15]3[C:10]([CH:11]=[CH:12][CH:13]=[CH:14]3)=[N:9]2)=[CH:4][CH:3]=1.[N-:34]=[N+:35]=[N-:36].[Na+].Cl.C([N:41]([CH2:44][CH3:45])CC)C>CN(C=O)C>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[C:16]([CH:17]([CH:28]3[CH2:29][CH2:30][CH2:31][CH2:32][CH2:33]3)[O:26][CH2:27][C:2]3[CH:7]=[CH:6][C:45]([C:44]4[N:34]=[N:35][NH:36][N:41]=4)=[CH:4][CH:3]=3)=[C:15]3[C:10]([CH:11]=[CH:12][CH:13]=[CH:14]3)=[N:9]2)=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 11130Triethylamine hydrochlorideHCID 33557Sodium AzideHCID 67131158HCID 67131158, compound

Product 1

HCID 45111519HCID 45111519, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

In analogy to the procedure described in example 31, [rac]-4-{[2-(4-chloro-phenyl)-2H-indazol-3-yl]-cyclohexyl-methoxymethyl}-benzonitrile (example 46) was reacted with sodium azide in the presence of triethylamine hydrochloride in DMF to obtain the title compound as brown solid. MS: m/e=499.3 [M+H+].

Sources & evidence

ORD record
ord-7d40d381d3d94f04a0dcb5ca8ddfc235
Source dataset
uspto-grants-2011_08
Patent number
US08008505B2

Reaction notes

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