Triethylamine hydrochloride → HCID 45111521, compound

HRID 1678673Notes

Reaction equation

HRID 1678673 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:16]([C:17]([CH:28]3[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]3)([O:26][CH3:27])C3C=CC(C#N)=CC=3)=[C:15]3[C:10]([CH:11]=[C:12]([F:35])[C:13]([F:34])=[CH:14]3)=[N:9]2)=[CH:4][CH:3]=1.[N-:36]=[N+:37]=[N-:38].[Na+].Cl.C([N:43]([CH2:46][CH3:47])CC)C>CN(C=O)C>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[C:16]([CH:17]([CH:28]3[CH2:29][CH2:30][CH2:31][CH2:32][CH2:33]3)[O:26][CH2:27][C:2]3[CH:7]=[CH:6][C:47]([C:46]4[N:36]=[N:37][NH:38][N:43]=4)=[CH:4][CH:3]=3)=[C:15]3[C:10]([CH:11]=[C:12]([F:35])[C:13]([F:34])=[CH:14]3)=[N:9]2)=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 11130Triethylamine hydrochlorideHCID 33557Sodium AzideHCID 67131061HCID 67131061, compound

Product 1

HCID 45111521HCID 45111521, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

In analogy to the procedure described in example 31, [rac]-4-{[2-(4-chloro-phenyl)-5,6-difluoro-2H-indazol-3-yl]-cyclohexyl-methoxymethyl}-benzonitrile (example 48) was reacted with sodium azide in the presence of triethylamine hydrochloride in DMF to obtain the title compound as brown oil. MS: m/e=535.2 [M+H+].

Sources & evidence

ORD record
ord-e849c1a77aa44e23a9d7a58316c00fd7
Source dataset
uspto-grants-2011_08
Patent number
US08008505B2

Reaction notes

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