Triethylamine hydrochloride → HCID 178505410, compound

HRID 1678674Notes

Reaction equation

HRID 1678674 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:16]([CH:17]([CH:28]3[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]3)[O:18][C:19]3[CH:26]=[CH:25][C:22]([C:23]#[N:24])=[CH:21][C:20]=3[F:27])=[C:15]3[C:10]([CH:11]=[C:12]([F:35])[C:13]([F:34])=[CH:14]3)=[N:9]2)=[CH:4][CH:3]=1.[N-:36]=[N+:37]=[N-:38].[Na+].Cl.C(N(CC)CC)C>CN(C=O)C>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:16]([CH:17]([CH:28]3[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]3)[O:18][C:19]3[CH:26]=[CH:25][C:22]([C:23]4[NH:38][N:37]=[N:36][N:24]=4)=[CH:21][C:20]=3[F:27])=[C:15]3[C:10]([CH:11]=[C:12]([F:35])[C:13]([F:34])=[CH:14]3)=[N:9]2)=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 11130Triethylamine hydrochlorideHCID 33557Sodium AzideHCID 45111210HCID 45111210, compound

Product 1

HCID 178505410HCID 178505410, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

In analogy to the procedure described in example 31, [rac]-4-{[2-(4-chloro-phenyl)-5,6-difluoro-2H-indazol-3-yl]-cyclohexyl-methoxy}-3-fluoro-benzonitrile (example 35) was reacted with sodium azide in the presence of triethylamine hydrochloride in DMF to obtain the title compound as yellow solid. MS: m/e=539.2 [M+H+].

Sources & evidence

ORD record
ord-31fda203027c486e852c15681b441de6
Source dataset
uspto-grants-2011_08
Patent number
US08008505B2

Reaction notes

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