Lithium Hydroxide → HCID 45111942, compound

HRID 1678691Notes

Reaction equation

HRID 1678691 reaction equation
C[O:2][C:3](=[O:37])[C:4]1[CH:9]=[CH:8][C:7]([NH:10][C:11](=[O:35])[CH:12]([C:19]2[N:20]([C:28]3[CH:33]=[CH:32][C:31]([Cl:34])=[CH:30][CH:29]=3)[N:21]=[C:22]3[C:27]=2[CH2:26][CH2:25][CH2:24][CH2:23]3)[CH:13]2[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]2)=[C:6]([Cl:36])[CH:5]=1.[OH-].[Li+]>C1COCC1>[Cl:36][C:6]1[CH:5]=[C:4]([CH:9]=[CH:8][C:7]=1[NH:10][C:11](=[O:35])[CH:12]([C:19]1[N:20]([C:28]2[CH:29]=[CH:30][C:31]([Cl:34])=[CH:32][CH:33]=2)[N:21]=[C:22]2[C:27]=1[CH2:26][CH2:25][CH2:24][CH2:23]2)[CH:13]1[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]1)[C:3]([OH:37])=[O:2]

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 67131191HCID 67131191, compound

Product 1

HCID 45111942HCID 45111942, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

In analogy to the procedure described in example 60.2, [rac]-3-chloro-4-{2-[2-(4-chloro-phenyl)-4,5,6,7-tetrahydro-2H-indazol-3-yl]-2-cyclohexyl-acetylamino}-benzoic acid methyl ester was treated with aqueous lithium hydroxide solution in THF to give the title compound as off-white solid. MS: m/e=526.0 [M+H+].

Sources & evidence

ORD record
ord-6760900d7b0b4076ab1bf4dcdc0807fd
Source dataset
uspto-grants-2011_08
Patent number
US08008505B2

Reaction notes

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