HCID 178521903, compound → HCID 178478199, compound

HRID 1678696Notes

Reaction equation

HRID 1678696 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:16]([CH:17]([CH:33]3[CH2:38][CH2:37][CH2:36][CH2:35][CH2:34]3)[C:18]([NH:20][C:21]3[CH:26]=[CH:25][C:24]([C:27]4[NH:31][N:30]=[N:29][N:28]=4)=[CH:23][C:22]=3F)=O)=[C:15]3[C:10]([CH2:11][CH2:12][CH2:13][CH2:14]3)=[N:9]2)=[CH:4][CH:3]=1>C1COCC1>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:16]([CH:17]([CH:33]3[CH2:38][CH2:37][CH2:36][CH2:35][CH2:34]3)[CH2:18][NH:20][C:21]3[CH:26]=[CH:25][C:24]([C:27]4[NH:31][N:30]=[N:29][N:28]=4)=[CH:23][CH:22]=3)=[C:15]3[C:10]([CH2:11][CH2:12][CH2:13][CH2:14]3)=[N:9]2)=[CH:4][CH:3]=1

Participants

3

Reactant 1

HCID 178521903HCID 178521903, compound

Product 1

HCID 178478199HCID 178478199, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

In analogy to the procedure described in example 29.1, [rac]-2-[2-(4-chloro-phenyl)-4,5,6,7-tetrahydro-2H-indazol-3-yl]-2-cyclohexyl-N-[2-fluoro-4-(1H-tetrazol-5-yl)-phenyl]-acetamide (example 58) was reduced using borane-dimethylsulfide complex in THF to give the title compound as brown solid. MS: m/e=502.0 [M+H+]1.

Sources & evidence

ORD record
ord-e46532f455c8484d827447aa92d9822f
Source dataset
uspto-grants-2011_08
Patent number
US08008505B2

Reaction notes

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