反应详情

4a-(m-Methoxyphenyl)-1,3-diketo-1,2,3,4,4a,5,6,7-octahydroisoquinoline (6 g) in 75 ml of anhydrous dimethylformamide was added to a 55% suspension of sodium hydride in mineral oil (1.2 g) in 50 ml of dimethylformamide at 70°. The reaction mixture was heated for one hour at 80° and then cooled to 25°. p-Methylphenethyl mesylate (7.0 g) was added and the reaction heated at 70° for 18 hours. It was poured into water and extracted with ether. The residue after evaporation of the ether was chromatographed on 800 g. of Florisil. This yielded 4.4 g, mp 134°-140°; recrystallized from ethanol, mp 149°-151°.

1. temperatureThe reaction mixture was heated for one hour at 80°
2. temperaturecooled to 25°
3. temperaturethe reaction heated at 70° for 18 hours
4. extractionextracted with ether
5. customThe residue after evaporation of the ether
6. customwas chromatographed on 800 g
7. customrecrystallized from ethanol, mp 149°-151°