反应详情

温度

80 °C

Ethyl 2-bromo-5-thiazolecarboxylate (10 g), phenol (4.38 g) and potassium carbonate powder (11.7 g) are suspended in dimethylformamide (50 ml) and the suspension is stirred for 3 hours at 80° C. The reaction mixture is treated in the same manner as in Example 1 to give ethyl 2-phenoxy-5-thiazolecarboxylate (10.2 g) boiling at 127°-128° C at 1 mmHg.

1. additionThe reaction mixture is treated in the same manner as in Example 1