Hydrochloric Acid → HCID 131711046, compound

HRID 1678950Notes

Reaction equation

HRID 1678950 reaction equation
C(Cl)(Cl)[Cl:2].Cl.[CH3:6][N:7]([CH3:30])[CH2:8][CH2:9][CH2:10][O:11][C:12]1[CH:17]=[CH:16][C:15]([CH:18]=[C:19]2[C:24](=[O:25])[NH:23][C:22]3[CH:26]=[CH:27][CH:28]=[CH:29][C:21]=3[S:20]2)=[CH:14][CH:13]=1>C(O)C>[ClH:2].[CH3:30][N:7]([CH3:6])[CH2:8][CH2:9][CH2:10][O:11][C:12]1[CH:13]=[CH:14][C:15]([CH:18]=[C:19]2[C:24](=[O:25])[NH:23][C:22]3[CH:26]=[CH:27][CH:28]=[CH:29][C:21]=3[S:20]2)=[CH:16][CH:17]=1

Participants

5

Reactant 3

HCID 313Hydrochloric Acid2×HCID 6212ChloroformHCID 54253248HCID 54253248, compound

Product 1

HCID 131711046HCID 131711046, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 6 g. of the above product in 30 ml. of chloroform is treated with one equivalent of hydrochloric acid in ethanol to yield 5.6 g. of yellow solid; m.p. 224°-226°. A solution of this material in 110 ml. of hot methanol is concentrated to approximately half its volume, and then cooled overnight to yield 4.2 g. of yellow crystalline 2-[[4-[3-(dimethylamino)propoxy]phenyl]methylene]-2H-1,4-benzothiazin-3(4H)-one; hydrochloride (1:1); m.p. 224°-226°.

Workup

  1. customto yield 5.6 g
  2. concentrationof hot methanol is concentrated to approximately half its volume
  3. temperaturecooled overnight
  4. customto yield 4.2 g

Sources & evidence

ORD record
ord-9d43e827bbe443138771e576c1b399c9
Source dataset
uspto-grants-1978_03
Patent number
US04078062

Reaction notes

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