Hydrochloric Acid → HCID 675281, compound

HRID 1679178Notes

Reaction equation

HRID 1679178 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=O)[CH:9]([CH3:11])[CH3:10])=[CH:4][CH:3]=1.Cl.[NH2:14][OH:15].[OH-].[Na+].Cl>O.C(O)C>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[N:14][OH:15])[CH:9]([CH3:11])[CH3:10])=[CH:4][CH:3]=1

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 443297Hydroxyamine hydrochlorideHCID 5768291-Propanone, 2-methyl-1-(4-methylphenyl)-

Product 1

HCID 675281HCID 675281, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

3.2 g of 5A, 7.4 g of hydroxylamine hydrochloride, 40 ml of ethanol and 80 ml of water were mixed. 4.4 g of sodium hydroxide was added to the stirred mixture at room temperature. The mixture was stirred for 4 hours at reflux temperature, cooled, poured into cold dilute hydrochloric acid and extracted with methylene chloride. The extract was dried (MgSO4) and stripped of solvent and the product was chromatographed (silica gel, methylene chloride/ether) to give 1-(4-methylphenyl)-2-methyl-1-propanone oxime (5B), as a liquid, boiling point not determined.

Workup

  1. temperatureat reflux temperature
  2. temperaturecooled
  3. extractionextracted with methylene chloride
  4. dry with materialThe extract was dried (MgSO4)
  5. customthe product was chromatographed (silica gel, methylene chloride/ether)

Sources & evidence

ORD record
ord-66194dc0deaa45e78c643d517f9030f0
Source dataset
uspto-grants-1978_03
Patent number
US04079149

Reaction notes

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