1-Chlorohexane → 1-Methyl-2-(5-aminomethylhexylisoxazol-3-yl)-5-nitroimidazole

HRID 1679302Notes

Reaction equation

HRID 1679302 reaction equation
[CH2:1](Cl)CCCCC.[CH3:8][N:9]1[C:13]([N+:14]([O-:16])=[O:15])=[CH:12][N:11]=[C:10]1[C:17]1[C:21]([CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][NH:28]CCCCC(C)C)=[CH:20][O:19][N:18]=1>CN(C)C=O>[CH3:8][N:9]1[C:13]([N+:14]([O-:16])=[O:15])=[CH:12][N:11]=[C:10]1[C:17]1[C:21]([CH2:22][CH2:23][CH2:24][CH2:25][CH:26]([CH2:27][NH2:28])[CH3:1])=[CH:20][O:19][N:18]=1

Participants

4

Reactant 2

HCID 109921-ChlorohexaneHCID 706217761-Methyl-2-(5-methylhexylaminohexylisoxazol-3-yl)-5-nitroimidazole

Product 1

HCID 203624761-Methyl-2-(5-aminomethylhexylisoxazol-3-yl)-5-nitroimidazole

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The product prepared above is treated in a similar fashion with hexyl chloride in dimethylformamide for two hours. The recrystallized product is identified as 1-methyl-2-(5-methylhexylaminohexylisoxazol-3-yl)-5-nitroimidazole.

Workup

  1. customThe product prepared

Sources & evidence

ORD record
ord-238700bc9a0d401a80f9c6e10a9b0ef2
Source dataset
uspto-grants-1978_03
Patent number
US04080340

Reaction notes

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