Tert-Butylamine → HCID 20362847, compound

HRID 1679381Notes

Reaction equation

HRID 1679381 reaction equation
[Cl:1][C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][C:9]=2[O:11][CH2:12][CH:13]2[O:15][CH2:14]2)[NH:4][CH:3]=1.[C:16]([NH2:20])([CH3:19])([CH3:18])[CH3:17]>O1CCOCC1>[C:16]([NH:20][CH2:14][CH:13]([OH:15])[CH2:12][O:11][C:9]1[CH:8]=[CH:7][CH:6]=[C:5]2[C:10]=1[C:2]([Cl:1])=[CH:3][NH:4]2)([CH3:19])([CH3:18])[CH3:17]

Participants

4

Reactant 2

HCID 6385Tert-ButylamineHCID 20362850HCID 20362850, compound

Product 1

HCID 20362847HCID 20362847, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A solution of 1.13 g of 3-chloro-4-(2,3-epoxypropoxy)indole (prepared in manner analogous to the preparation of the starting material in Example 1, m.p. 107°-110°) and 2.2 g tert.butylamine in 15 ml of dioxan are boiled under reflux for 5 hours, evaporated to dryness and the title compound recrystallised from ether/petroleum ether. M.p. 95°-97°.

Workup

  1. temperatureunder reflux for 5 hours
  2. customevaporated to dryness
  3. customthe title compound recrystallised from ether/petroleum ether

Sources & evidence

ORD record
ord-9545d257f42549b28e912e5e2d8979e8
Source dataset
uspto-grants-1978_03
Patent number
US04080463

Reaction notes

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