反应详情

Dimethylaminoethylchloride hydrochloride (1.5g) was added to 2,2-dimethyl-4-(4-trifluoromethylphenylchroman-7-ol (1.0g), potassium carbonate (4.0g) and potassium iodide (1.5g) in acetone (50 ml) and the mixture refluxed for 2 days. The mixture was filtered and the acetone was evaporated under reduced pressure. The resulting crude oil was chromatographed on alumina. Elution with ether: petrol (1 : 1) gave a clear oil which after dissolution in dry ether and passage of dry hydrogen chloride through the solution yielded the required chroman as the hydrochloride salt (0.35g), m.p. 200°-203° C.

1. temperaturethe mixture refluxed for 2 days
2. filtrationThe mixture was filtered
3. customthe acetone was evaporated under reduced pressure
4. customThe resulting crude oil was chromatographed on alumina
5. washElution with ether: petrol (1 : 1)
6. customgave a clear oil which