Dichloromethane → HCID 20361443, compound

HRID 1679608Notes

Reaction equation

HRID 1679608 reaction equation
[C:1]1([S:7](Cl)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH:11][C:12]1[CH:13]=[C:14]([CH:20]=[CH:21][CH:22]=1)[NH:15][C:16](=[O:19])[CH2:17][Br:18].C(Cl)Cl>C(N(CC)CC)C>[C:1]1([S:7]([O:11][C:12]2[CH:13]=[C:14]([CH:20]=[CH:21][CH:22]=2)[NH:15][C:16](=[O:19])[CH2:17][Br:18])(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

5

Reactant 3

HCID 6344DichloromethaneHCID 7369Benzenesulfonyl chlorideHCID 127641052-Bromo-N-(3-hydroxyphenyl)acetamide

Product 1

HCID 20361443HCID 20361443, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

To a mixture of 4.4 g. of benzene sulfonyl chloride and 5.7 g. of 3'-hydroxy bromoacetanilide in 100 ml. of methylene chloride is added dropwise 2.6 g. of triethylamine. The product is recovered by washing with cold water, drying and removal of the solvent. There is obtained 9.0 g. of the title compound, nD30 = 1.5830.

Workup

  1. additionTo a mixture of 4.4 g
  2. customThe product is recovered
  3. washby washing with cold water
  4. customdrying
  5. customremoval of the solvent
  6. customThere is obtained 9.0 g

Sources & evidence

ORD record
ord-012a25342ff94fd1b475ac06fd60b738
Source dataset
uspto-grants-1978_03
Patent number
US04081474

Reaction notes

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